This brief discusses the safety and security of Pakistani nuclear facilities in the face of terrorism. It discusses US involvement in protecting the facilities and the steps Pakistan has taken to prevent their misuse or misappropriation. With the assault on the office of the Inter-Services Intelligence (ISI) in Peshawar on 13 November 2009, which left at least 20 people dead, including 10 ISI officials, the Taliban-Al Qaeda nexus has once again demonstrated that it is capable of hitting the supposedly well-guarded targets representing the power and authority of the state. The Head Office of the Federal Investigation Agency in Lahore was bombed in October this year. A similar attack took place in 2008. Since 2007, attacks have been launched on military, air force and naval personnel and officials. On the other hand, the media also reported that some terrorists had tried to enter the restricted area where the nuclear facilities are located, but they were stopped at the outer security ring.